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Jessica the Liberated is one of the more flexible Defenders in the game. She has a well rounded kit that is sufficient at covering an awful lot of scenarios. As with a lot of flexible generalists, her total Mastery grades are fairly high which reflects the broad investment needed to cover a broad variety of roles. In other words, the gap between her primary and secondary skills is relatively low. However, keep in mind her individual grades are a touch low in the modern meta since both her ceiling and her role compression don’t measure up as well to the current powrcreep. Those skills are S2 and S3, with S3 coming out ahead in general usage. They are quite different, and as said, you want flexible options in a unit built around flexibility. In fact, the differences are too many and too wide ranging to cover here without this write-up becoming a full article of its own. However, that said, her S3 is usually more impactful. S2 has higher DPS, but often struggles against DEF, while S3 has a very high DPH and a long stun that's easy to time which allows her to tackle a wider variety of enemies. Her S1 may be worth a look if you really like Jessica or AFK skills. Mastery drops the wind